Degeneration of Intervertebral Disc : Correlation between MRI , Histological and Transcripts Analysis
نویسندگان
چکیده
Galway, Ireland Degeneration of Intervertebral Disc: Correlation between MRI, Histological and Transcripts Analysis. Johann Clouet, Marianne Pot-Vaucel, ClaireVinatier, Martial Masson, Julie Lesoeur, Yan Chérel, Lydie Guigand, Marion Fusellier, Borhane Fellah, Olivier Gauthier, Pierre Weiss, Gaël Grimandi, Jérôme Guicheux Corresponding Author: [email protected] 1 Inserm U791, group of "Skeletal Tissue Engineering and Physiopathology", Nantes, France, 2 GRAFTYS SA, Aix en Provence, France, 3 INRA UMR703, National Veterinary School of Nantes, France and 4 Preclinical animal research centre, National Veterinary School of Nantes, France.
منابع مشابه
The relationship between MRI and histology in a rat model of intervertebral disc degeneration
Objectives: To establish a slowly progressive, reproducible rat model of disc degeneration and investigate the relationship between MRI and histology in the long-term progression of disc degeneration. Materials and methods: The intervertebral discs of caudal spine in rats were punctured laterally, using 20-gauge sterile needles, 5 mm depth from the skin to the middle of the appropriate disc. Th...
متن کاملProtective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic component of the Cannabis sativa with protective and anti-inflammatory properties. However, possible therapeutic effects of cannabidiol on intervertebral disc degeneration have no...
متن کاملQuantitative T2 relaxation time and magnetic transfer ratio predict endplate biochemical content of intervertebral disc degeneration in a canine model
BACKGROUND Direct measurement of disc biochemical content is impossible in vivo. Therefore, magnetic resonance imaging (MRI) is used to evaluate disc health. Unfortunately, current clinical imaging techniques do not adequately assess degeneration, especially in the early stage of cartilage endplate, and subchondral bone zone (CEPZ). Therefore, this study aimed to investigate the sensitivity of ...
متن کاملMicroscopic assessment of degenerated intervertebral disc: clinical implications and possible therapeutic challenge.
AIM To investigate a possible correlation between the histological and morphometric properties of herniated intervertebral disc, clinical and magnetic resonance imaging (MRI) characteristics of patients with lumbar disc degeneration (LDD). MATERIALS AND METHODS Thirty six patients with LDD were clinically evaluated using Japanese Orthopaedic Association Score (JOAS), visual analogue scale (VA...
متن کاملExperimental model of intervertebral disc degeneration by needle puncture in Wistar rats
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and ...
متن کامل